1wof: Difference between revisions

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[[Image:1wof.gif|left|200px]]<br /><applet load="1wof" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1wof.gif|left|200px]]
caption="1wof, resolution 2.0&Aring;" />
 
'''Crystal Structure Of SARS-CoV Mpro in Complex with an Inhibitor N1'''<br />
{{Structure
|PDB= 1wof |SIZE=350|CAPTION= <scene name='initialview01'>1wof</scene>, resolution 2.0&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=I12:N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]-L-ALANYL-L-VALYL-N~1~-((1S)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE'>I12</scene>
|ACTIVITY=
|GENE=
}}
 
'''Crystal Structure Of SARS-CoV Mpro in Complex with an Inhibitor N1'''
 


==Overview==
==Overview==
Line 7: Line 16:


==About this Structure==
==About this Structure==
1WOF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus] with <scene name='pdbligand=I12:'>I12</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WOF OCA].  
1WOF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WOF OCA].  


==Reference==
==Reference==
Design of wide-spectrum inhibitors targeting coronavirus main proteases., Yang H, Xie W, Xue X, Yang K, Ma J, Liang W, Zhao Q, Zhou Z, Pei D, Ziebuhr J, Hilgenfeld R, Yuen KY, Wong L, Gao G, Chen S, Chen Z, Ma D, Bartlam M, Rao Z, PLoS Biol. 2005 Oct;3(10):e324. Epub 2005 Sep 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16128623 16128623]
Design of wide-spectrum inhibitors targeting coronavirus main proteases., Yang H, Xie W, Xue X, Yang K, Ma J, Liang W, Zhao Q, Zhou Z, Pei D, Ziebuhr J, Hilgenfeld R, Yuen KY, Wong L, Gao G, Chen S, Chen Z, Ma D, Bartlam M, Rao Z, PLoS Biol. 2005 Oct;3(10):e324. Epub 2005 Sep 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16128623 16128623]
[[Category: Human sars coronavirus]]
[[Category: Human sars coronavirus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Yang, K.]]
[[Category: Yang, K.]]
[[Category: I12]]
[[Category: I12]]
[[Category: anti-parallel a-helices]]
[[Category: anti-parallel a-helice]]
[[Category: anti-parallel b-barrel]]
[[Category: anti-parallel b-barrel]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:46:37 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:59:35 2008''
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