2kcx: Difference between revisions
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{{STRUCTURE_2kcx| PDB=2kcx | SCENE= }} | {{STRUCTURE_2kcx| PDB=2kcx | SCENE= }} | ||
===Solution NMR Structure of Kazal-1 Domain of Human Follistatin-related protein 3 (FSTL-3). Northeast Structural Genomics Target HR6186A.=== | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/FSTL3_HUMAN FSTL3_HUMAN]] Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FSTL3_HUMAN FSTL3_HUMAN]] Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.<ref>PMID:11948405</ref><ref>PMID:15451575</ref><ref>PMID:15574124</ref><ref>PMID:16336961</ref><ref>PMID:17868029</ref><ref>PMID:17878677</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2kcx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCX OCA]. | [[2kcx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCX OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Anderson, S.]] | [[Category: Anderson, S.]] | ||
