2k60: Difference between revisions

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~~[[Image:2k60.png|left|200px]]~~

===NMR structure of calcium-loaded STIM1 EF-SAM===

===~~NMR structure~~ of calcium-~~loaded STIM1 EF~~-~~SAM===~~

==Disease==

[[http://www.uniprot.org/uniprot/STIM1_HUMAN STIM1_HUMAN]] Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:[http://omim.org/entry/612783 612783]]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.<ref>PMID:19420366</ref>

~~{{ABSTRACT_PUBMED_018854159}}~~

==Function==

[[http://www.uniprot.org/uniprot/STIM1_HUMAN STIM1_HUMAN]] Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.<ref>PMID:9377559</ref><ref>PMID:16005298</ref><ref>PMID:15866891</ref><ref>PMID:16208375</ref><ref>PMID:16807233</ref><ref>PMID:16766533</ref><ref>PMID:16733527</ref><ref>PMID:16537481</ref><ref>PMID:22464749</ref>

==About this Structure==

[[2k60]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K60 OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Ikura, M.]]

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@@ Line 1: / Line 1: @@
-[[Image:2k60.png|left|200px]]
 {{STRUCTURE_2k60|  PDB=2k60  |  SCENE=  }}
+===NMR structure of calcium-loaded STIM1 EF-SAM===
+{{ABSTRACT_PUBMED_018854159}}
-===NMR structure of calcium-loaded STIM1 EF-SAM===
+==Disease==
+[[http://www.uniprot.org/uniprot/STIM1_HUMAN STIM1_HUMAN]] Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:[http://omim.org/entry/612783 612783]]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.<ref>PMID:19420366</ref>
-{{ABSTRACT_PUBMED_018854159}}
+==Function==
+[[http://www.uniprot.org/uniprot/STIM1_HUMAN STIM1_HUMAN]] Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.<ref>PMID:9377559</ref><ref>PMID:16005298</ref><ref>PMID:15866891</ref><ref>PMID:16208375</ref><ref>PMID:16807233</ref><ref>PMID:16766533</ref><ref>PMID:16733527</ref><ref>PMID:16537481</ref><ref>PMID:22464749</ref>
 ==About this Structure==
 [[2k60]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K60 OCA].
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Ikura, M.]]