1x81: Difference between revisions

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[[Image:1x81.gif|left|200px]]<br /><applet load="1x81" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1x81.gif|left|200px]]
caption="1x81, resolution 3.5&Aring;" />
 
'''Farnesyl transferase structure of Jansen compound'''<br />
{{Structure
|PDB= 1x81 |SIZE=350|CAPTION= <scene name='initialview01'>1x81</scene>, resolution 3.5&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=JAN:6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE'>JAN</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Protein_farnesyltransferase Protein farnesyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.58 2.5.1.58]
|GENE=
}}
 
'''Farnesyl transferase structure of Jansen compound'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1X81 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=JAN:'>JAN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein_farnesyltransferase Protein farnesyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.58 2.5.1.58] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X81 OCA].  
1X81 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X81 OCA].  


==Reference==
==Reference==
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors., Li Q, Claiborne A, Li T, Hasvold L, Stoll VS, Muchmore S, Jakob CG, Gu W, Cohen J, Hutchins C, Frost D, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2004 Nov 1;14(21):5367-70. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15454228 15454228]
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors., Li Q, Claiborne A, Li T, Hasvold L, Stoll VS, Muchmore S, Jakob CG, Gu W, Cohen J, Hutchins C, Frost D, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2004 Nov 1;14(21):5367-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15454228 15454228]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Protein farnesyltransferase]]
[[Category: Protein farnesyltransferase]]
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[[Category: fanesyltransferase]]
[[Category: fanesyltransferase]]


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