1xbb: Difference between revisions

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[[Image:1xbb.jpg|left|200px]]<br /><applet load="1xbb" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1xbb.jpg|left|200px]]
caption="1xbb, resolution 1.57&Aring;" />
 
'''Crystal structure of the syk tyrosine kinase domain with Gleevec'''<br />
{{Structure
|PDB= 1xbb |SIZE=350|CAPTION= <scene name='initialview01'>1xbb</scene>, resolution 1.57&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=STI:4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE'>STI</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2]
|GENE= SYK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of the syk tyrosine kinase domain with Gleevec'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1XBB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=STI:'>STI</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XBB OCA].  
1XBB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XBB OCA].  


==Reference==
==Reference==
A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase., Atwell S, Adams JM, Badger J, Buchanan MD, Feil IK, Froning KJ, Gao X, Hendle J, Keegan K, Leon BC, Muller-Dieckmann HJ, Nienaber VL, Noland BW, Post K, Rajashankar KR, Ramos A, Russell M, Burley SK, Buchanan SG, J Biol Chem. 2004 Dec 31;279(53):55827-32. Epub 2004 Oct 26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15507431 15507431]
A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase., Atwell S, Adams JM, Badger J, Buchanan MD, Feil IK, Froning KJ, Gao X, Hendle J, Keegan K, Leon BC, Muller-Dieckmann HJ, Nienaber VL, Noland BW, Post K, Rajashankar KR, Ramos A, Russell M, Burley SK, Buchanan SG, J Biol Chem. 2004 Dec 31;279(53):55827-32. Epub 2004 Oct 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15507431 15507431]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: spleen typrosine kinase]]
[[Category: spleen typrosine kinase]]
[[Category: sti-571]]
[[Category: sti-571]]
[[Category: structural genomics]]
[[Category: structural genomic]]
[[Category: structural genomix]]
[[Category: structural genomix]]
[[Category: syk]]
[[Category: syk]]


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