2yqk: Difference between revisions
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{{STRUCTURE_2yqk| PDB=2yqk | SCENE= }} | {{STRUCTURE_2yqk| PDB=2yqk | SCENE= }} | ||
===Solution structure of the SANT domain in Arginine-glutamic acid dipeptide (RE) repeats=== | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/RERE_HUMAN RERE_HUMAN]] Note=A chromosomal aberration involving RERE is found in the neuroblastoma cell line NGP. Translocation t(1;15)(p36.2;q24). | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RERE_HUMAN RERE_HUMAN]] Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.<ref>PMID:11331249</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2yqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQK OCA]. | [[2yqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQK OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: He, F.]] | [[Category: He, F.]] | ||
Revision as of 11:50, 24 March 2013
Solution structure of the SANT domain in Arginine-glutamic acid dipeptide (RE) repeats
Disease
[RERE_HUMAN] Note=A chromosomal aberration involving RERE is found in the neuroblastoma cell line NGP. Translocation t(1;15)(p36.2;q24).
Function
[RERE_HUMAN] Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.[1]
About this Structure
2yqk is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- He, F.
- Inoue, M.
- Kadirvel, S.
- Kigawa, T.
- Muto, Y.
- RSGI, RIKEN Structural Genomics/Proteomics Initiative.
- Shirouzu, M.
- Tarada, T.
- Yokoyama, S.
- National project on protein structural and functional analyse
- Nppsfa
- Riken structural genomics/proteomics initiative
- Rsgi
- Sant domain
- Structural genomic
- Structure genomic
- Transcription-apoptosis complex
