1xg4: Difference between revisions

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[[Image:1xg4.gif|left|200px]]<br /><applet load="1xg4" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1xg4.gif|left|200px]]
caption="1xg4, resolution 1.6&Aring;" />
 
'''Crystal Structure of the C123S 2-Methylisocitrate Lyase Mutant from Escherichia coli in complex with the inhibitor isocitrate'''<br />
{{Structure
|PDB= 1xg4 |SIZE=350|CAPTION= <scene name='initialview01'>1xg4</scene>, resolution 1.6&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=ICT:ISOCITRIC ACID'>ICT</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Methylisocitrate_lyase Methylisocitrate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.30 4.1.3.30]
|GENE= prpB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''Crystal Structure of the C123S 2-Methylisocitrate Lyase Mutant from Escherichia coli in complex with the inhibitor isocitrate'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1XG4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ICT:'>ICT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Methylisocitrate_lyase Methylisocitrate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.30 4.1.3.30] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XG4 OCA].  
1XG4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XG4 OCA].  


==Reference==
==Reference==
Crystal structures of 2-methylisocitrate lyase in complex with product and with isocitrate inhibitor provide insight into lyase substrate specificity, catalysis and evolution., Liu S, Lu Z, Han Y, Melamud E, Dunaway-Mariano D, Herzberg O, Biochemistry. 2005 Mar 1;44(8):2949-62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15723538 15723538]
Crystal structures of 2-methylisocitrate lyase in complex with product and with isocitrate inhibitor provide insight into lyase substrate specificity, catalysis and evolution., Liu S, Lu Z, Han Y, Melamud E, Dunaway-Mariano D, Herzberg O, Biochemistry. 2005 Mar 1;44(8):2949-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15723538 15723538]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Methylisocitrate lyase]]
[[Category: Methylisocitrate lyase]]
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[[Category: isocitrate lyase superfamily]]
[[Category: isocitrate lyase superfamily]]


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