3ans: Difference between revisions
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{{STRUCTURE_3ans| PDB=3ans | SCENE= }} | {{STRUCTURE_3ans| PDB=3ans | SCENE= }} | ||
===Human soluble epoxide hydrolase in complex with a synthetic inhibitor=== | ===Human soluble epoxide hydrolase in complex with a synthetic inhibitor=== | ||
{{ABSTRACT_PUBMED_21192659}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN]] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3ans]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3ans]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANS OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021192659</ref><references group="xtra"/> | <ref group="xtra">PMID:021192659</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Soluble epoxide hydrolase]] | [[Category: Soluble epoxide hydrolase]] | ||
[[Category: Chiyo, N.]] | [[Category: Chiyo, N.]] | ||
