1xmj: Difference between revisions

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[[Image:1xmj.gif|left|200px]]<br /><applet load="1xmj" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1xmj.gif|left|200px]]
caption="1xmj, resolution 2.30&Aring;" />
 
'''Crystal structure of human deltaF508 human NBD1 domain with ATP'''<br />
{{Structure
|PDB= 1xmj |SIZE=350|CAPTION= <scene name='initialview01'>1xmj</scene>, resolution 2.30&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=ATP:ADENOSINE-5'-TRIPHOSPHATE'>ATP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Channel-conductance-controlling_ATPase Channel-conductance-controlling ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.49 3.6.3.49]
|GENE= CFTR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of human deltaF508 human NBD1 domain with ATP'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1XMJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ATP:'>ATP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Channel-conductance-controlling_ATPase Channel-conductance-controlling ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.49 3.6.3.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XMJ OCA].  
1XMJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XMJ OCA].  


==Reference==
==Reference==
Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure., Lewis HA, Zhao X, Wang C, Sauder JM, Rooney I, Noland BW, Lorimer D, Kearins MC, Conners K, Condon B, Maloney PC, Guggino WB, Hunt JF, Emtage S, J Biol Chem. 2005 Jan 14;280(2):1346-53. Epub 2004 Nov 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15528182 15528182]
Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure., Lewis HA, Zhao X, Wang C, Sauder JM, Rooney I, Noland BW, Lorimer D, Kearins MC, Conners K, Condon B, Maloney PC, Guggino WB, Hunt JF, Emtage S, J Biol Chem. 2005 Jan 14;280(2):1346-53. Epub 2004 Nov 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15528182 15528182]
[[Category: Channel-conductance-controlling ATPase]]
[[Category: Channel-conductance-controlling ATPase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: cftr; nbd1 domain; deltaf508; cystic fibrosis; nucleotide-binding domain 1]]
[[Category: cftr; nbd1 domain; deltaf508; cystic fibrosis; nucleotide-binding domain 1]]


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