1xod: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1xod.gif|left|200px]] | [[Image:1xod.gif|left|200px]] | ||
'''Crystal structure of X. tropicalis Spred1 EVH-1 domain''' | {{Structure | ||
|PDB= 1xod |SIZE=350|CAPTION= <scene name='initialview01'>1xod</scene>, resolution 1.15Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | |||
|ACTIVITY= | |||
|GENE= Spred1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8364 Xenopus tropicalis]) | |||
}} | |||
'''Crystal structure of X. tropicalis Spred1 EVH-1 domain''' | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
1XOD is a [ | 1XOD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOD OCA]. | ||
==Reference== | ==Reference== | ||
1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family., Harmer NJ, Sivak JM, Amaya E, Blundell TL, FEBS Lett. 2005 Feb 14;579(5):1161-6. PMID:[http:// | 1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family., Harmer NJ, Sivak JM, Amaya E, Blundell TL, FEBS Lett. 2005 Feb 14;579(5):1161-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15710406 15710406] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Xenopus tropicalis]] | [[Category: Xenopus tropicalis]] | ||
| Line 23: | Line 32: | ||
[[Category: sprouty]] | [[Category: sprouty]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:12:27 2008'' | ||
Revision as of 13:12, 20 March 2008
| |||||||||||||
| 1xod, resolution 1.15Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | GOL | ||||||||||||
| Gene: | Spred1 (Xenopus tropicalis) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of X. tropicalis Spred1 EVH-1 domain
Overview
The recently described Spred protein family has been implicated in the modulation of receptor tyrosine kinase signalling. We report the crystal structure of the Enabled/vasodilator-stimulated phosphoprotein homology-1 (EVH1) domain from Xenopus tropicalis Spred1, solved to 1.15 A resolution. This structure confirms that the Spred EVH1 adopts the pleckstrin-homology fold, with a similar secondary structure to Enabled. A translation of one of the peptide-binding groove beta-strands narrows this groove, whilst one end of the groove shows structural flexibility. We propose that Spred1 will bind peptides that are less proline-rich than other EVH1 domains, with conformational changes indicating an induced fit.
About this Structure
1XOD is a Single protein structure of sequence from Xenopus tropicalis. Full crystallographic information is available from OCA.
Reference
1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family., Harmer NJ, Sivak JM, Amaya E, Blundell TL, FEBS Lett. 2005 Feb 14;579(5):1161-6. PMID:15710406
Page seeded by OCA on Thu Mar 20 15:12:27 2008
