3dj7: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "3dj7" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image: | ==Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 130.== | ||
<StructureSection load='3dj7' size='340' side='right' caption='[[3dj7]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3dj7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DJ7 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AK7:1-(5-{2-[(6-AMINO-5-BROMOPYRIMIDIN-4-YL)AMINO]ETHYL}-1,3-THIAZOL-2-YL)-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA'>AK7</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3d14|3d14]], [[3d15|3d15]], [[3d2i|3d2i]], [[3d2k|3d2k]], [[2c6d|2c6d]], [[3dj6|3dj6]], [[3dj5|3dj5]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Aurka, Stk6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dj7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3dj7 PDBsum]</span></td></tr> | |||
</table> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dj/3dj7_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Serine/threonine protein kinase|Serine/threonine protein kinase]] | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
[[ | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Elling, R A | [[Category: Elling, R A]] | ||
[[Category: Erlanson, D A | [[Category: Erlanson, D A]] | ||
[[Category: Hansen, S K | [[Category: Hansen, S K]] | ||
[[Category: Romanowski, M J | [[Category: Romanowski, M J]] | ||
[[Category: Tangonan, B T | [[Category: Tangonan, B T]] | ||
[[Category: Yang, W | [[Category: Yang, W]] | ||
[[Category: Aurora some]] | [[Category: Aurora some]] | ||
[[Category: Fragment-based drug discovery]] | [[Category: Fragment-based drug discovery]] | ||
