2v7d: Difference between revisions

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~~[[Image:2v7d.png|left|200px]]~~

===14-3-3 PROTEIN ZETA IN COMPLEX WITH THR758 PHOSPHORYLATED INTEGRIN BETA2 PEPTIDE===

===14-~~3-3 PROTEIN ZETA IN COMPLEX WITH THR758 PHOSPHORYLATED INTEGRIN BETA2 PEPTIDE===~~

==Disease==

[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref><ref>PMID:1346613</ref><ref>PMID:1968911</ref><ref>PMID:1694220</ref><ref>PMID:1590804</ref><ref>PMID:1352501</ref><ref>PMID:1347532</ref><ref>PMID:7686755</ref><ref>PMID:9884339</ref><ref>PMID:20529581</ref><ref>PMID:20549317</ref>

~~{{ABSTRACT_PUBMED_18550856}}~~

==Function==

[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:18587400</ref>

==About this Structure==

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==Reference==

[[Category: Bos taurus]]

[[Category: Takala, H.]]

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@@ Line 1: / Line 1: @@
-[[Image:2v7d.png|left|200px]]
 {{STRUCTURE_2v7d|  PDB=2v7d  |  SCENE=  }}
+===14-3-3 PROTEIN ZETA IN COMPLEX WITH THR758 PHOSPHORYLATED INTEGRIN BETA2 PEPTIDE===
+{{ABSTRACT_PUBMED_18550856}}
-===14-3-3 PROTEIN ZETA IN COMPLEX WITH THR758 PHOSPHORYLATED INTEGRIN BETA2 PEPTIDE===
+==Disease==
+[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref><ref>PMID:1346613</ref><ref>PMID:1968911</ref><ref>PMID:1694220</ref><ref>PMID:1590804</ref><ref>PMID:1352501</ref><ref>PMID:1347532</ref><ref>PMID:7686755</ref><ref>PMID:9884339</ref><ref>PMID:20529581</ref><ref>PMID:20549317</ref>
-{{ABSTRACT_PUBMED_18550856}}
+==Function==
+[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:18587400</ref>
 ==About this Structure==
@@ Line 11: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:018550856</ref><references group="xtra"/>
+<ref group="xtra">PMID:018550856</ref><references group="xtra"/><references/>
 [[Category: Bos taurus]]
 [[Category: Takala, H.]]