2rll: Difference between revisions
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{{STRUCTURE_2rll| PDB=2rll | SCENE= }} | {{STRUCTURE_2rll| PDB=2rll | SCENE= }} | ||
===CCR5 Nt(7-15)=== | |||
{{ABSTRACT_PUBMED_17901336}} | |||
===CCR5 | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Genetic variation in CCR5 is associated with susceptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:[http://omim.org/entry/612522 612522]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:19073967</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.<ref>PMID:8639485</ref><ref>PMID:8663314</ref><ref>PMID:8699119</ref><ref>PMID:8649511</ref><ref>PMID:8649512</ref><ref>PMID:11323418</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017901336</ref><references group="xtra"/> | <ref group="xtra">PMID:017901336</ref><references group="xtra"/><references/> | ||
[[Category: Bewley, C A.]] | [[Category: Bewley, C A.]] | ||
[[Category: Lam, S N.]] | [[Category: Lam, S N.]] | ||
