1h6t: Difference between revisions
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==Overview== | ==Overview== | ||
Listeria monocytogenes is an opportunistic, food-borne human and animal, pathogen. Host cell invasion requires the action of the internalins A, (InlA) and B (InlB), which are members of a family of listerial, cell-surface proteins. Common to these proteins are three distinctive, N-terminal domains that have been shown to direct host cell-specific, invasion for InlA and InlB. Here, we present the high-resolution crystal, structures of these domains present in InlB and InlH, and show that they, constitute a single "internalin domain". In this internalin domain, a, central LRR region is flanked contiguously by a truncated EF-hand-like cap, and an immunoglobulin (Ig)-like fold. The extended beta-sheet, resulting, from the distinctive fusion of the LRR and the Ig-like folds, constitutes, an . | Listeria monocytogenes is an opportunistic, food-borne human and animal, pathogen. Host cell invasion requires the action of the internalins A, (InlA) and B (InlB), which are members of a family of listerial, cell-surface proteins. Common to these proteins are three distinctive, N-terminal domains that have been shown to direct host cell-specific, invasion for InlA and InlB. Here, we present the high-resolution crystal, structures of these domains present in InlB and InlH, and show that they, constitute a single "internalin domain". In this internalin domain, a, central LRR region is flanked contiguously by a truncated EF-hand-like cap, and an immunoglobulin (Ig)-like fold. The extended beta-sheet, resulting, from the distinctive fusion of the LRR and the Ig-like folds, constitutes, an adaptable concave interaction surface, which we propose is responsible, for the specific recognition of the host cellular binding partners during, infection. | ||
==About this Structure== | ==About this Structure== | ||
1H6T is a | 1H6T is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Structure known Active Site: NUL. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H6T OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: leucine rich repeat]] | [[Category: leucine rich repeat]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 13:19:00 2007'' | ||
