3bfo: Difference between revisions
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{{STRUCTURE_3bfo| PDB=3bfo | SCENE= }} | {{STRUCTURE_3bfo| PDB=3bfo | SCENE= }} | ||
===Crystal structure of Ig-like C2-type 2 domain of the human Mucosa-associated lymphoid tissue lymphoma translocation protein 1=== | |||
{{ABSTRACT_PUBMED_018164727}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref><ref>PMID:14695475</ref><ref>PMID:18264101</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018164727</ref><references group="xtra"/> | <ref group="xtra">PMID:018164727</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Akutsu, M.]] | [[Category: Akutsu, M.]] | ||
