2wr6: Difference between revisions
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{{STRUCTURE_2wr6| PDB=2wr6 | SCENE= }} | {{STRUCTURE_2wr6| PDB=2wr6 | SCENE= }} | ||
===STRUCTURE OF THE COMPLEX OF RBP4 WITH LINOLEIC ACID=== | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[http://omim.org/entry/180250 180250]]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. | |||
==About this Structure== | ==About this Structure== | ||
Revision as of 06:03, 25 March 2013
STRUCTURE OF THE COMPLEX OF RBP4 WITH LINOLEIC ACID
Disease
[RET4_HUMAN] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
Function
[RET4_HUMAN] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
About this Structure
2wr6 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
