1y5m: Difference between revisions

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[[Image:1y5m.gif|left|200px]]<br /><applet load="1y5m" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1y5m.gif|left|200px]]
caption="1y5m, resolution 2.3&Aring;" />
 
'''The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes'''<br />
{{Structure
|PDB= 1y5m |SIZE=350|CAPTION= <scene name='initialview01'>1y5m</scene>, resolution 2.3&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146]
|GENE= Hsd11b1, Hsd11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
}}
 
'''The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1Y5M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=NDP:'>NDP</scene> and <scene name='pdbligand=OCT:'>OCT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y5M OCA].  
1Y5M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y5M OCA].  


==Reference==
==Reference==
Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes., Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SR, Biochemistry. 2005 May 10;44(18):6948-57. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15865440 15865440]
Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes., Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SR, Biochemistry. 2005 May 10;44(18):6948-57. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15865440 15865440]
[[Category: 11-beta-hydroxysteroid dehydrogenase]]
[[Category: 11-beta-hydroxysteroid dehydrogenase]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: rossmann fold]]
[[Category: rossmann fold]]


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