1ya8: Difference between revisions

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[[Image:1ya8.gif|left|200px]]<br /><applet load="1ya8" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ya8.gif|left|200px]]
caption="1ya8, resolution 3.00&Aring;" />
 
'''Crystal Structure of Human Liver Carboxylesterase in complex with cleavage products of Mevastatin'''<br />
{{Structure
|PDB= 1ya8 |SIZE=350|CAPTION= <scene name='initialview01'>1ya8</scene>, resolution 3.00&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MVB:(1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY+DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL'>MVB</scene> and <scene name='pdbligand=SMB:2-METHYLBUTANOIC ACID'>SMB</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1]
|GENE=
}}
 
'''Crystal Structure of Human Liver Carboxylesterase in complex with cleavage products of Mevastatin'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1YA8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=SIA:'>SIA</scene>, <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=MVB:'>MVB</scene> and <scene name='pdbligand=SMB:'>SMB</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YA8 OCA].  
1YA8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YA8 OCA].  


==Reference==
==Reference==
Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil., Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR, J Mol Biol. 2005 Sep 9;352(1):165-77. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16081098 16081098]
Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil., Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR, J Mol Biol. 2005 Sep 9;352(1):165-77. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16081098 16081098]
[[Category: Carboxylesterase]]
[[Category: Carboxylesterase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: mevastatin]]
[[Category: mevastatin]]


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