4elk: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[ | ==Crystal structure of the Hy19.3 type II NKT TCR== | ||
<StructureSection load='4elk' size='340' side='right' caption='[[4elk]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4elk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ELK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ELK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4elm|4elm]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Valpha1 (mouse variable domain, human constant domain) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Vbeta16 (mouse variable domain, human constant domain) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4elk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4elk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4elk RCSB], [http://www.ebi.ac.uk/pdbsum/4elk PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Glycolipids presented by the major histocompatibility complex (MHC) class I homolog CD1d are recognized by natural killer T cells (NKT cells) characterized by either a semi-invariant T cell antigen receptor (TCR) repertoire (type I NKT cells or iNKT cells) or a relatively variable TCR repertoire (type II NKT cells). Here we describe the structure of a type II NKT cell TCR in complex with CD1d-lysosulfatide. Both TCR alpha-chains and TCR beta-chains made contact with the CD1d molecule with a diagonal footprint, typical of MHC-TCR interactions, whereas the antigen was recognized exclusively with a single TCR chain, similar to the iNKT cell TCR. Type II NKT cell TCRs, therefore, recognize CD1d-sulfatide complexes by a distinct recognition mechanism characterized by the TCR-binding features of both iNKT cells and conventional peptide-reactive T cells. | |||
Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens.,Girardi E, Maricic I, Wang J, Mac TT, Iyer P, Kumar V, Zajonc DM Nat Immunol. 2012 Sep;13(9):851-6. doi: 10.1038/ni.2371. Epub 2012 Jul 22. PMID:22820602<ref>PMID:22820602</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Girardi, E | [[Category: Girardi, E]] | ||
[[Category: Iyer, P | [[Category: Iyer, P]] | ||
[[Category: Kumar, V | [[Category: Kumar, V]] | ||
[[Category: Mac, T T | [[Category: Mac, T T]] | ||
[[Category: Maricic, I | [[Category: Maricic, I]] | ||
[[Category: Wang, J | [[Category: Wang, J]] | ||
[[Category: Zajonc, D M | [[Category: Zajonc, D M]] | ||
[[Category: Antigen presentation]] | [[Category: Antigen presentation]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Type ii nkt cell]] | [[Category: Type ii nkt cell]] | ||
