3pnw: Difference between revisions
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{{STRUCTURE_3pnw| PDB=3pnw | SCENE= }} | {{STRUCTURE_3pnw| PDB=3pnw | SCENE= }} | ||
===Crystal Structure of the tudor domain of human TDRD3 in complex with an anti-TDRD3 FAB=== | ===Crystal Structure of the tudor domain of human TDRD3 in complex with an anti-TDRD3 FAB=== | ||
{{ABSTRACT_PUBMED_23219464}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TDRD3_HUMAN TDRD3_HUMAN]] Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.<ref>PMID:18632687</ref> <ref>PMID:15955813</ref> <ref>PMID:21172665</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
*[[Antibody|Antibody]] | *[[Antibody|Antibody]] | ||
==Reference== | |||
<ref group="xtra">PMID:023219464</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Synthetic construct]] | [[Category: Synthetic construct]] | ||
