3zgn: Difference between revisions
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[[ | ==Crystal structures of Escherichia coli IspH in complex with TMBPP a potent inhibitor of the methylerythritol phosphate pathway== | ||
<StructureSection load='3zgn' size='340' side='right' caption='[[3zgn]], [[Resolution|resolution]] 1.95Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3zgn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZGN FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zgl|3zgl]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zgn RCSB], [http://www.ebi.ac.uk/pdbsum/3zgn PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref> | |||
==See Also== | |||
*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase|4-hydroxy-3-methylbut-2-enyl diphosphate reductase]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
== | </StructureSection> | ||
[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]] | [[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Barbier, E | [[Category: Barbier, E]] | ||
[[Category: Borel, F | [[Category: Borel, F]] | ||
[[Category: Ferrer, J L | [[Category: Ferrer, J L]] | ||
[[Category: Janthawornpong, K | [[Category: Janthawornpong, K]] | ||
[[Category: Kratsutsky, S | [[Category: Kratsutsky, S]] | ||
[[Category: Poulter, C Dale | [[Category: Poulter, C Dale]] | ||
[[Category: Rohmer, M | [[Category: Rohmer, M]] | ||
[[Category: Seemann, M | [[Category: Seemann, M]] | ||
[[Category: 4fe-4s cluster]] | [[Category: 4fe-4s cluster]] | ||
[[Category: Inhibitor]] | [[Category: Inhibitor]] | ||
[[Category: Mep pathway]] | [[Category: Mep pathway]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
