1yho: Difference between revisions

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[[Image:1yho.gif|left|200px]]<br /><~~applet load~~=~~"1yho" size~~=~~"350" color~~=~~"white" frame~~=~~"true" align~~=~~"right" spinBox~~=~~"true"~~

[[Image:1yho.gif|left|200px]]

~~caption~~=~~"1yho" />~~

'''Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures'''~~<br />~~

{{Structure

|PDB= 1yho |SIZE=350|CAPTION= <scene name='initialview01'>1yho</scene>

|SITE=

|LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=TRR:2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM'>TRR</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]

|GENE=

}}

'''Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures'''

==Disease==

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==About this Structure==

1YHO is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~] with <scene name='pdbligand=NDP:'>NDP</scene> and <scene name='pdbligand=TRR:'>TRR</scene> as [http://en.wikipedia.org/wiki/ligands ligands~~]. ~~Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHO OCA].

1YHO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHO OCA].

==Reference==

Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH., Kovalevskaya NV, Smurnyy YD, Polshakov VI, Birdsall B, Bradbury AF, Frenkiel T, Feeney J, J Biomol NMR. 2005 Sep;33(1):69-72. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~16222560 16222560]

Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH., Kovalevskaya NV, Smurnyy YD, Polshakov VI, Birdsall B, Bradbury AF, Frenkiel T, Feeney J, J Biomol NMR. 2005 Sep;33(1):69-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16222560 16222560]

[[Category: Dihydrofolate reductase]]

[[Category: Homo sapiens]]

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[[Category: inhibitor/enzyme complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 16~~:05:28 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:22:59 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1yho.gif|left|200px]]<br /><applet load="1yho" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1yho.gif|left|200px]]
-caption="1yho" />
-'''Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures'''<br />
+ {{Structure
+|PDB= 1yho |SIZE=350|CAPTION= <scene name='initialview01'>1yho</scene>
+|SITE=
+|LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=TRR:2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM'>TRR</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]
+|GENE=
+}}
+'''Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures'''
 ==Disease==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-YHO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NDP:'>NDP</scene> and <scene name='pdbligand=TRR:'>TRR</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHO OCA].
+YHO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHO OCA].
 ==Reference==
-Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH., Kovalevskaya NV, Smurnyy YD, Polshakov VI, Birdsall B, Bradbury AF, Frenkiel T, Feeney J, J Biomol NMR. 2005 Sep;33(1):69-72. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16222560 16222560]
+Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH., Kovalevskaya NV, Smurnyy YD, Polshakov VI, Birdsall B, Bradbury AF, Frenkiel T, Feeney J, J Biomol NMR. 2005 Sep;33(1):69-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16222560 16222560]
 [[Category: Dihydrofolate reductase]]
 [[Category: Homo sapiens]]
@@ Line 21: / Line 30: @@
 [[Category: inhibitor/enzyme complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:05:28 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:22:59 2008''