3eb8: Difference between revisions

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[[~~Image~~:3eb8.~~png|left|200px~~]]

==VirA==

== Structural highlights ==

<table><tr><td colspan='2'>[[3eb8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EB8 FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">virA, CP0181, pWR501_0191 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 Shigella flexneri])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eb8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eb8 RCSB], [http://www.ebi.ac.uk/pdbsum/3eb8 PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

VirA, an essential virulence factor in Shigella disease pathogenesis, is involved in the uptake, motility, and cell-to-cell spread of Shigella organisms within the human host. These functions have been attributed to a VirA protease activity and a mechanism of microtubule destruction via tubulin degradation [Yoshida, S., et al. (2006) Science 314, 985-989]. We report functional and crystallographic data indicating a novel VirA structure that lacks these activities but highlights the homology to the EspG virulence factor of pathogenic Escherichia coli.

~~{{STRUCTURE_3eb8| PDB=3eb8 | SCENE= }}~~

Structural and functional studies indicate that Shigella VirA is not a protease and does not directly destabilize microtubules.,Germane KL, Ohi R, Goldberg MB, Spiller BW Biochemistry. 2008 Sep 30;47(39):10241-3. Epub 2008 Sep 3. PMID:18763811<ref>PMID:18763811</ref>

~~===VirA===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_18763811}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[3eb8]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Shigella_flexneri Shigella flexneri]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3EB8 OCA].~~

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:018763811<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Shigella flexneri]]

[[Category: Germane, K L.]]

[[Category: Germane, K L]]

[[Category: Spiller, B W.]]

[[Category: Spiller, B W]]

[[Category: Alpha helix]]

[[Category: Beta sheet]]

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-[[Image:3eb8.png|left|200px]]
+==VirA==
+<StructureSection load='3eb8' size='340' side='right' caption='[[3eb8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3eb8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EB8 FirstGlance]. <br>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">virA, CP0181, pWR501_0191 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 Shigella flexneri])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eb8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eb8 RCSB], [http://www.ebi.ac.uk/pdbsum/3eb8 PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+VirA, an essential virulence factor in Shigella disease pathogenesis, is involved in the uptake, motility, and cell-to-cell spread of Shigella organisms within the human host. These functions have been attributed to a VirA protease activity and a mechanism of microtubule destruction via tubulin degradation [Yoshida, S., et al. (2006) Science 314, 985-989]. We report functional and crystallographic data indicating a novel VirA structure that lacks these activities but highlights the homology to the EspG virulence factor of pathogenic Escherichia coli.
-{{STRUCTURE_3eb8|  PDB=3eb8  |  SCENE=  }}
+Structural and functional studies indicate that Shigella VirA is not a protease and does not directly destabilize microtubules.,Germane KL, Ohi R, Goldberg MB, Spiller BW Biochemistry. 2008 Sep 30;47(39):10241-3. Epub 2008 Sep 3. PMID:18763811<ref>PMID:18763811</ref>
-===VirA===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_18763811}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[3eb8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EB8 OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:018763811</ref><references group="xtra"/>
 [[Category: Shigella flexneri]]
-[[Category: Germane, K L.]]
+[[Category: Germane, K L]]
-[[Category: Spiller, B W.]]
+[[Category: Spiller, B W]]
 [[Category: Alpha helix]]
 [[Category: Beta sheet]]