1yki: Difference between revisions

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[[Image:1yki.gif|left|200px]]<br /><applet load="1yki" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1yki.gif|left|200px]]
caption="1yki, resolution 1.70&Aring;" />
 
'''The structure of E. coli nitroreductase bound with the antibiotic nitrofurazone'''<br />
{{Structure
|PDB= 1yki |SIZE=350|CAPTION= <scene name='initialview01'>1yki</scene>, resolution 1.70&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=NFZ:NITROFURAZONE'>NFZ</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene> and <scene name='pdbligand=DMS:DIMETHYL SULFOXIDE'>DMS</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/6,7-dihydropteridine_reductase 6,7-dihydropteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.34 1.5.1.34]
|GENE= nfnB, dprA, nfsB, nfsI, ntr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''The structure of E. coli nitroreductase bound with the antibiotic nitrofurazone'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1YKI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=FMN:'>FMN</scene>, <scene name='pdbligand=NFZ:'>NFZ</scene>, <scene name='pdbligand=CIT:'>CIT</scene> and <scene name='pdbligand=DMS:'>DMS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/6,7-dihydropteridine_reductase 6,7-dihydropteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.34 1.5.1.34] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKI OCA].  
1YKI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKI OCA].  


==Reference==
==Reference==
Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme., Race PR, Lovering AL, Green RM, Ossor A, White SA, Searle PF, Wrighton CJ, Hyde EI, J Biol Chem. 2005 Apr 8;280(14):13256-64. Epub 2005 Jan 31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15684426 15684426]
Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme., Race PR, Lovering AL, Green RM, Ossor A, White SA, Searle PF, Wrighton CJ, Hyde EI, J Biol Chem. 2005 Apr 8;280(14):13256-64. Epub 2005 Jan 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15684426 15684426]
[[Category: 6,7-dihydropteridine reductase]]
[[Category: 6,7-dihydropteridine reductase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: oxygen-insensitive nad(p)h nitroreductase]]
[[Category: oxygen-insensitive nad(p)h nitroreductase]]


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