1ykr: Difference between revisions

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[[Image:1ykr.gif|left|200px]]<br /><applet load="1ykr" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ykr.gif|left|200px]]
caption="1ykr, resolution 1.8&Aring;" />
 
'''Crystal structure of cdk2 with an aminoimidazo pyridine inhibitor'''<br />
{{Structure
|PDB= 1ykr |SIZE=350|CAPTION= <scene name='initialview01'>1ykr</scene>, resolution 1.8&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=628:4-{[6-(2,6-DICHLOROBENZOYL)IMIDAZO[1,2-A]PYRIDIN-2-YL]AMINO}BENZENESULFONAMIDE'>628</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1]
|GENE= CDK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of cdk2 with an aminoimidazo pyridine inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1YKR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=628:'>628</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKR OCA].  
1YKR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKR OCA].  


==Reference==
==Reference==
Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases., Hamdouchi C, Zhong B, Mendoza J, Collins E, Jaramillo C, De Diego JE, Robertson D, Spencer CD, Anderson BD, Watkins SA, Zhang F, Brooks HB, Bioorg Med Chem Lett. 2005 Apr 1;15(7):1943-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15780638 15780638]
Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases., Hamdouchi C, Zhong B, Mendoza J, Collins E, Jaramillo C, De Diego JE, Robertson D, Spencer CD, Anderson BD, Watkins SA, Zhang F, Brooks HB, Bioorg Med Chem Lett. 2005 Apr 1;15(7):1943-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15780638 15780638]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: cell cycle division protein kinase 2]]
[[Category: cell cycle division protein kinase 2]]


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