1yks: Difference between revisions
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[[Image:1yks.gif|left|200px]] | [[Image:1yks.gif|left|200px]] | ||
'''Crystal structure of yellow fever virus NS3 helicase''' | {{Structure | ||
|PDB= 1yks |SIZE=350|CAPTION= <scene name='initialview01'>1yks</scene>, resolution 1.8Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Flavivirin Flavivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.91 3.4.21.91] | |||
|GENE= | |||
}} | |||
'''Crystal structure of yellow fever virus NS3 helicase''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1YKS is a [ | 1YKS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Yellow_fever_virus Yellow fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKS OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing., Wu J, Bera AK, Kuhn RJ, Smith JL, J Virol. 2005 Aug;79(16):10268-77. PMID:[http:// | Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing., Wu J, Bera AK, Kuhn RJ, Smith JL, J Virol. 2005 Aug;79(16):10268-77. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16051820 16051820] | ||
[[Category: Flavivirin]] | [[Category: Flavivirin]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: yellow fever virus]] | [[Category: yellow fever virus]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:24:08 2008'' | ||
Revision as of 13:24, 20 March 2008
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| 1yks, resolution 1.8Å | |||||||||||||
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| Activity: | Flavivirin, with EC number 3.4.21.91 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of yellow fever virus NS3 helicase
Overview
Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes residues 187 to 623. Two familiar helicase domains bind nucleotide in a triphosphate pocket without base recognition, providing a site for nonspecific hydrolysis of nucleoside triphosphates and RNA triphosphate. The third, C-terminal domain has a unique structure and is proposed to function in RNA and protein recognition. The organization of the three domains indicates that cleavage of the viral polyprotein NS3-NS4A junction occurs in trans.
About this Structure
1YKS is a Single protein structure of sequence from Yellow fever virus. Full crystallographic information is available from OCA.
Reference
Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing., Wu J, Bera AK, Kuhn RJ, Smith JL, J Virol. 2005 Aug;79(16):10268-77. PMID:16051820
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