1ym1: Difference between revisions

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[[Image:1ym1.gif|left|200px]]<br /><applet load="1ym1" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ym1.gif|left|200px]]
caption="1ym1, resolution 1.12&Aring;" />
 
'''X-ray crystallographic structure of CTX-M-9 beta-lactamase complexed with a boronic acid inhibitor (SM2)'''<br />
{{Structure
|PDB= 1ym1 |SIZE=350|CAPTION= <scene name='initialview01'>1ym1</scene>, resolution 1.12&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=SM2:(1R)-1-(2-THIENYLACETYLAMINO)-1-(3-CARBOXYPHENYL)METHYLBORONIC ACID'>SM2</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]
|GENE= CTX-M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''X-ray crystallographic structure of CTX-M-9 beta-lactamase complexed with a boronic acid inhibitor (SM2)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1YM1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=SM2:'>SM2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YM1 OCA].  
1YM1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YM1 OCA].  


==Reference==
==Reference==
Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases., Chen Y, Shoichet B, Bonnet R, J Am Chem Soc. 2005 Apr 20;127(15):5423-34. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15826180 15826180]
Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases., Chen Y, Shoichet B, Bonnet R, J Am Chem Soc. 2005 Apr 20;127(15):5423-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15826180 15826180]
[[Category: Beta-lactamase]]
[[Category: Beta-lactamase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: transition state]]
[[Category: transition state]]


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