Group:MUZIC:ALP: Difference between revisions
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==Introduction | ==Introduction== | ||
The '''ALP subfamily''' (α-'''A'''ctinin-associated '''L'''IM domain '''P'''roteins) comprises four PDZ/LIM domain proteins of the cytoskeleton. Protein members of this subfamily include: '''ALP''' (also known as PDLIM3)<ref name="r1">PMID:9334352</ref>, '''CLP36''' (also known as hCLIM1 (in human)<ref>PMID:10022510</ref>, Elfin (in mouse)<ref>PMID:11596114</ref>, or PDLIM1), '''RIL''' (or PDLIM4) and '''Mystique''' (or SLIM, PDLIM2)<ref name=a>PMID:15505042</ref><ref name=b>PMID:15659642</ref>. | The '''ALP subfamily''' (α-'''A'''ctinin-associated '''L'''IM domain '''P'''roteins) comprises four PDZ/LIM domain proteins of the cytoskeleton. Protein members of this subfamily include: '''ALP''' (also known as PDLIM3)<ref name="r1">PMID:9334352</ref>, '''CLP36''' (also known as hCLIM1 (in human)<ref>PMID:10022510</ref>, Elfin (in mouse)<ref>PMID:11596114</ref>, or PDLIM1), '''RIL''' (or PDLIM4) and '''Mystique''' (or SLIM, PDLIM2)<ref name=a>PMID:15505042</ref><ref name=b>PMID:15659642</ref>. | ||
On the basis of structural similarities, the ALP subfamily are related to the [http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Enigma_Family Enigma subfamily], possessing [http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=PDZ&BLAST=DUMMY PDZ] and [http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=LIM&BLAST=DUMMY LIM] domains, as well as internal motifs ''viz'' ALP-like motif (AM) and ZASP-like motif (ZM). However, the ALP subfamily differs from the [http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Enigma_Family Enigma subfamily] as each member of the ALP subfamily possess an N-terminal PDZ domain and only '''one''' C-terminal LIM domain. | On the basis of structural similarities, the ALP subfamily are related to the [http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Enigma_Family Enigma subfamily], possessing [http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=PDZ&BLAST=DUMMY PDZ] and [http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=LIM&BLAST=DUMMY LIM] domains, as well as internal motifs ''viz'' ALP-like motif (AM) and ZASP-like motif (ZM). However, the ALP subfamily differs from the [http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Enigma_Family Enigma subfamily] as each member of the ALP subfamily possess an N-terminal PDZ domain and only '''one''' C-terminal LIM domain. | ||
