4h33: Difference between revisions
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[[ | ==Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes, tetragonal crystal form== | ||
<StructureSection load='4h33' size='340' side='right' caption='[[4h33]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4h33]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes_egd-e Listeria monocytogenes egd-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H33 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4h37|4h37]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lmo2059 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=169963 Listeria monocytogenes EGD-e])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h33 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h33 RCSB], [http://www.ebi.ac.uk/pdbsum/4h33 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Voltage-gated K(+) channels underlie the electrical excitability of cells. Each subunit of the functional tetramer consists of the tandem fusion of two modules, an N-terminal voltage-sensor and a C-terminal pore. To investigate how sensor coupling to the pore generates voltage-dependent channel opening, we solved the crystal structure and characterized the function of a voltage-gated K(+) channel pore in a lipid membrane. The structure of a functional channel in a membrane environment at 3.1 A resolution establishes an unprecedented connection between channel structure and function. The structure is unique in delineating an ion-occupied ready to conduct selectivity filter, a confined aqueous cavity, and a closed activation gate, embodying a dynamic entity trapped in an unstable closed state. | |||
Crystal Structure of a Voltage-gated K+ Channel Pore Module in a Closed State in Lipid Membranes.,Santos JS, Asmar-Rovira GA, Han GW, Liu W, Syeda R, Cherezov V, Baker KA, Stevens RC, Montal M J Biol Chem. 2012 Dec 14;287(51):43063-70. doi: 10.1074/jbc.M112.415091. Epub, 2012 Oct 24. PMID:23095758<ref>PMID:23095758</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Listeria monocytogenes egd-e]] | [[Category: Listeria monocytogenes egd-e]] | ||
[[Category: Asmar-Rovira, G A | [[Category: Asmar-Rovira, G A]] | ||
[[Category: Baker, K A | [[Category: Baker, K A]] | ||
[[Category: Cherezov, V | [[Category: Cherezov, V]] | ||
[[Category: Han, G W | [[Category: Han, G W]] | ||
[[Category: Liu, W | [[Category: Liu, W]] | ||
[[Category: Montal, M | [[Category: Montal, M]] | ||
[[Category: Santos, J S | [[Category: Santos, J S]] | ||
[[Category: Stevens, R C | [[Category: Stevens, R C]] | ||
[[Category: Syeda, R | [[Category: Syeda, R]] | ||
[[Category: Bilayer]] | [[Category: Bilayer]] | ||
[[Category: Ion channel]] | [[Category: Ion channel]] | ||
Revision as of 09:39, 10 December 2014
Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes, tetragonal crystal form
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