4gaw: Difference between revisions
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{{STRUCTURE_4gaw| PDB=4gaw | SCENE= }} | {{STRUCTURE_4gaw| PDB=4gaw | SCENE= }} | ||
===Crystal structure of active human granzyme H=== | ===Crystal structure of active human granzyme H=== | ||
{{ABSTRACT_PUBMED_23269243}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GRAH_HUMAN GRAH_HUMAN]] Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.<ref>PMID:22156497</ref> <ref>PMID:23269243</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4gaw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAW OCA]. | [[4gaw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAW OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023269243</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Fan, Z.]] | [[Category: Fan, Z.]] | ||
