3zhp: Difference between revisions
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{{STRUCTURE_3zhp| PDB=3zhp | SCENE= }} | {{STRUCTURE_3zhp| PDB=3zhp | SCENE= }} | ||
===Human MST3 (STK24) in complex with MO25beta=== | ===Human MST3 (STK24) in complex with MO25beta=== | ||
{{ABSTRACT_PUBMED_23296203}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CB39L_HUMAN CB39L_HUMAN]] Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity). [[http://www.uniprot.org/uniprot/STK24_HUMAN STK24_HUMAN]] Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.<ref>PMID:16314523</ref> <ref>PMID:17046825</ref> <ref>PMID:19604147</ref> <ref>PMID:19855390</ref> <ref>PMID:19782762</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3zhp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZHP OCA]. | [[3zhp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZHP OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
| Line 19: | Line 22: | ||
[[Category: Mehellou, Y.]] | [[Category: Mehellou, Y.]] | ||
[[Category: Szklarz, M.]] | [[Category: Szklarz, M.]] | ||
[[Category: | [[Category: VonDelft, F.]] | ||
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Mo25]] | [[Category: Mo25]] | ||
