1ysv: Difference between revisions
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[[Image:1ysv.gif|left|200px]] | [[Image:1ysv.gif|left|200px]] | ||
'''Solution structure of the central region of the human GluR-B R/G pre-mRNA''' | {{Structure | ||
|PDB= 1ysv |SIZE=350|CAPTION= <scene name='initialview01'>1ysv</scene> | |||
|SITE= | |||
|LIGAND= | |||
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'''Solution structure of the central region of the human GluR-B R/G pre-mRNA''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1YSV is a [ | 1YSV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA]. | ||
==Reference== | ==Reference== | ||
A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:[http:// | A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15840813 15840813] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Allain, F H.]] | [[Category: Allain, F H.]] | ||
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[[Category: structure]] | [[Category: structure]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:27:02 2008'' | ||
Revision as of 13:27, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Solution structure of the central region of the human GluR-B R/G pre-mRNA
Overview
Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2.
About this Structure
1YSV is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:15840813
Page seeded by OCA on Thu Mar 20 15:27:02 2008
