Group:MUZIC:CARP: Difference between revisions
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'''Introduction''' | '''Introduction''' | ||
The cardiac ankyrin repeat protein (CARP/Ankrd1) belongs together with the ankyrin repeat domain 2 (Ankrd2/Arpp) and the diabetes associated ankyrin repeat protein (DARP) to a conserved muscle ankyrin repeat protein (MARP) family<ref name='one'>PMID 14583192</ref>. CARP/Ankrd1 has been independently identified by several groups as a cytokine-inducible transcriptional regulator, a protein that interacts with the transcriptional factor YB-1 and a cardiac doxorubicin-responsive protein<ref name='two'>PMID 7730328</ref>,<ref name='three'>PMID 9043061</ref>. In physiological tissues, Ankrd1 is highly expressed in cardiac muscle and is detectable in skeletal muscles | The cardiac ankyrin repeat protein (CARP/Ankrd1) belongs together with the ankyrin repeat domain 2 (Ankrd2/Arpp) and the diabetes associated ankyrin repeat protein (DARP) to a conserved muscle ankyrin repeat protein (MARP) family<ref name='one'>PMID 14583192</ref>. CARP/Ankrd1 has been independently identified by several groups as a cytokine-inducible transcriptional regulator, a protein that interacts with the transcriptional factor YB-1 and a cardiac doxorubicin-responsive protein<ref name='two'>PMID 7730328</ref>,<ref name='three'>PMID 9043061</ref>. In physiological tissues, Ankrd1 is highly expressed in cardiac muscle and is detectable in skeletal muscles<ref name='three'>PMID 9043061</ref>. It is an early differentiation marker during cardiogenesis with a high expression level in developing heart<ref | ||
name='three'>PMID 9043061</ref>, <ref name='four'>PMID 9278441</ref>. Mutations in the ANKRD1 gene are responsible for human dilated cardiomyopathy | name='three'>PMID 9043061</ref>, <ref name='four'>PMID 9278441</ref>. Mutations in the ANKRD1 gene are responsible for human dilated cardiomyopathy<ref name='five'>PMID 14561590</ref>. | ||
== Sequence Annotation == | == Sequence Annotation == | ||
CARP is | CARP is comprising 319 amino acids and the sequences of the [http://http://www.uniprot.org/uniprot/ Q15327 human], [http://www.uniprot.org/uniprot/ Q9CR42 mouse] and [http://www.uniprot.org/uniprot/ Q9TU71 rabbit] proteins are available from Uniprot. | ||
{{STRUCTURE_1n0r| PDB=1n11}} | {{STRUCTURE_1n0r| PDB=1n11}} | ||
