4hmn: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)===

~~The entry 4hmn is ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

~~Authors~~: ~~Turnbull, A~~.P., ~~Flanagan,~~ J.U., ~~Atwell~~, G.J., Heinrich, D.M., Jamieson, S.M.F., ~~Brooke, D.G~~., ~~Silva, S~~., Rigoreau, L.J.M.~~, Trivier, E., Soudy, C.,~~ Samlal, S.S.~~, Owen, P.J.,~~ Schroeder, E., ~~Raynham~~, T., ~~Denny~~, W.A.

==About this Structure==

[[4hmn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMN OCA].

~~Description~~: ~~Crystal structure of human 17beta~~-~~hydroxysteroid dehydrogenase type 5 in~~ complex ~~with (4-(4-Chlorophenyl)piperazin-1~~-~~yl)(morpholino)methanone (24)~~

[[Category: Atwell, G J.]]

[[Category: Brooke, D G.]]

[[Category: Denny, W A.]]

[[Category: Flanagan, J U.]]

[[Category: Heinrich, D M.]]

[[Category: Jamieson, S M.F.]]

[[Category: Owen, P J.]]

[[Category: Raynham, T.]]

[[Category: Rigoreau, L J.M.]]

[[Category: Samlal, S S.]]

[[Category: Schroeder, E.]]

[[Category: Silva, S.]]

[[Category: Soudy, C.]]

[[Category: Trivier, E.]]

[[Category: Turnbull, A P.]]

[[Category: Aldo-keto reductase]]

[[Category: Oxidoreductase]]

[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

[[Category: Tim-barrel]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4hmn|  PDB=4hmn  |  SCENE=  }}
+===Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)===
-The entry 4hmn is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
-Authors: Turnbull, A.P., Flanagan, J.U., Atwell, G.J., Heinrich, D.M., Jamieson, S.M.F., Brooke, D.G., Silva, S., Rigoreau, L.J.M., Trivier, E., Soudy, C., Samlal, S.S., Owen, P.J., Schroeder, E., Raynham, T., Denny, W.A.
+==About this Structure==
+[[4hmn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMN OCA].
-Description: Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)
+[[Category: Atwell, G J.]]
+[[Category: Brooke, D G.]]
+[[Category: Denny, W A.]]
+[[Category: Flanagan, J U.]]
+[[Category: Heinrich, D M.]]
+[[Category: Jamieson, S M.F.]]
+[[Category: Owen, P J.]]
+[[Category: Raynham, T.]]
+[[Category: Rigoreau, L J.M.]]
+[[Category: Samlal, S S.]]
+[[Category: Schroeder, E.]]
+[[Category: Silva, S.]]
+[[Category: Soudy, C.]]
+[[Category: Trivier, E.]]
+[[Category: Turnbull, A P.]]
+[[Category: Aldo-keto reductase]]
+[[Category: Oxidoreductase]]
+[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
+[[Category: Tim-barrel]]