4i02: Difference between revisions
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{{STRUCTURE_4i02| PDB=4i02 | SCENE= }} | |||
===structure of the mutant Catabolite gene activator protein V140A=== | |||
{{ABSTRACT_PUBMED_24058293}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI]] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref> | |||
==About this Structure== | |||
[[4i02]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I02 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024058293</ref><references group="xtra"/><references/> | |||
[[Category: Escherichia coli k-12]] | |||
[[Category: Burnell, D.]] | |||
[[Category: Cann, M J.]] | |||
[[Category: McLeish, T C.B.]] | |||
[[Category: Pohl, E.]] | |||
[[Category: Rodgers, T.]] | |||
[[Category: Townsend, P D.]] | |||
[[Category: Wilson, M R.]] | |||
[[Category: Dna binding]] | |||
[[Category: Transcription]] | |||
Revision as of 09:30, 30 October 2013
structure of the mutant Catabolite gene activator protein V140A
Template:ABSTRACT PUBMED 24058293
Function
[CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.[1]
About this Structure
4i02 is a 6 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.
Reference
- Rodgers TL, Townsend PD, Burnell D, Jones ML, Richards SA, McLeish TC, Pohl E, Wilson MR, Cann MJ. Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors. PLoS Biol. 2013 Sep;11(9):e1001651. doi: 10.1371/journal.pbio.1001651. Epub 2013 , Sep 10. PMID:24058293 doi:https://dx.doi.org/10.1371/journal.pbio.1001651
