4ibr: Difference between revisions
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{{STRUCTURE_4ibr| PDB=4ibr | SCENE= }} | |||
===Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying G238S/E104K mutations=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX]] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors. | |||
==About this Structure== | |||
[[4ibr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IBR OCA]. | |||
[[Category: Beta-lactamase]] | |||
[[Category: Escherichia coli]] | |||
[[Category: Dellus-Gur, E.]] | |||
[[Category: Elias, M.]] | |||
[[Category: Tawfik, D S.]] | |||
[[Category: Toth-Petroczy, A.]] | |||
[[Category: Beta-lactamase]] | |||
[[Category: Hydrolase]] | |||
Revision as of 01:49, 4 April 2013
Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying G238S/E104K mutations
Function
[BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
About this Structure
4ibr is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
