4ime: Difference between revisions
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{{STRUCTURE_4ime| PDB=4ime | SCENE= }} | |||
===Crystal Structure of Pasteurella multocida N-Acetyl-D-Neuraminic acid lyase K164A Mutant=== | |||
{{ABSTRACT_PUBMED_24152047}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NANA_PASMU NANA_PASMU]] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (By similarity). | |||
==About this Structure== | |||
[[4ime]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Cylindrocarpon_theobromicola Cylindrocarpon theobromicola]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IME OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024152047</ref><references group="xtra"/><references/> | |||
[[Category: Cylindrocarpon theobromicola]] | |||
[[Category: N-acetylneuraminate lyase]] | |||
[[Category: Fisher, A J.]] | |||
[[Category: Huynh, N.]] | |||
[[Category: Lyase]] | |||
[[Category: Schiff base]] | |||
[[Category: Tim barrel]] | |||
Revision as of 07:42, 6 November 2013
Crystal Structure of Pasteurella multocida N-Acetyl-D-Neuraminic acid lyase K164A Mutant
Template:ABSTRACT PUBMED 24152047
Function
[NANA_PASMU] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (By similarity).
About this Structure
4ime is a 8 chain structure with sequence from Cylindrocarpon theobromicola. Full crystallographic information is available from OCA.
Reference
- Huynh N, Aye A, Li Y, Yu H, Cao H, Tiwari VK, Shin DW, Chen X, Fisher AJ. Structural basis for substrate specificity and mechanism of N-acetyl-D-neuraminic acid lyase from Pasteurella multocida. Biochemistry. 2013 Oct 23. PMID:24152047 doi:https://dx.doi.org/10.1021/bi4011754
