4ini: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4ini| PDB=4ini | SCENE= }} | |||
===Human Histidine Triad Nucleotide Binding Protein 2 with Bound AMP=== | |||
{{ABSTRACT_PUBMED_23659632}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HINT2_HUMAN HINT2_HUMAN]] Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.<ref>PMID:16762638</ref> <ref>PMID:18653718</ref> | |||
==About this Structure== | |||
[[4ini]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_aureorectus Streptomyces aureorectus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4INI OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023659632</ref><references group="xtra"/><references/> | |||
[[Category: Streptomyces aureorectus]] | |||
[[Category: Finzel, B C.]] | |||
[[Category: Maize, K M.]] | |||
[[Category: Wagner, C R.]] | |||
[[Category: Hint]] | |||
[[Category: Histidine triad]] | |||
[[Category: Hit]] | |||
[[Category: Hydrolase]] | |||
[[Category: Phosphoramidase]] | |||
Revision as of 15:31, 19 June 2013
Human Histidine Triad Nucleotide Binding Protein 2 with Bound AMP
Template:ABSTRACT PUBMED 23659632
Function
[HINT2_HUMAN] Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.[1] [2]
About this Structure
4ini is a 2 chain structure with sequence from Streptomyces aureorectus. Full crystallographic information is available from OCA.
Reference
- Maize KM, Wagner CR, Finzel BC. Structural characterization of human histidine triad nucleotide binding protein 2 (hHint2), a member of the histidine triad (HIT) superfamily. FEBS J. 2013 May 10. doi: 10.1111/febs.12330. PMID:23659632 doi:10.1111/febs.12330
- ↑ Martin J, Magnino F, Schmidt K, Piguet AC, Lee JS, Semela D, St-Pierre MV, Ziemiecki A, Cassio D, Brenner C, Thorgeirsson SS, Dufour JF. Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma. Gastroenterology. 2006 Jun;130(7):2179-88. PMID:16762638 doi:10.1053/j.gastro.2006.03.024
- ↑ Lenglet S, Antigny F, Vetterli L, Dufour JF, Rossier MF. Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis. Endocrinology. 2008 Nov;149(11):5461-9. doi: 10.1210/en.2008-0400. Epub 2008 Jul , 24. PMID:18653718 doi:10.1210/en.2008-0400
