4ipx: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4ipx|  PDB=4ipx  |  SCENE=  }}
===Analyzing the visible conformational substates of the FK506 binding protein FKBP12===
{{ABSTRACT_PUBMED_23688288}}


The entry 4ipx is ON HOLD
==Function==
[[http://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN]] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref> 


Authors: Chen, H., Mustafi, S.M., Li, H.M., LeMaster, D.M., Hernandez, G.
==About this Structure==
[[4ipx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IPX OCA].  


Description: Analyzing the visible conformational substates of the FK506 binding protein FKBP12
==Reference==
<ref group="xtra">PMID:023688288</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Chen, H.]]
[[Category: Hernandez, G.]]
[[Category: LeMaster, D M.]]
[[Category: Li, H M.]]
[[Category: Mustafi, S M.]]
[[Category: Isomerase]]
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