1yzc: Difference between revisions
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[[Image:1yzc.gif|left|200px]] | [[Image:1yzc.gif|left|200px]] | ||
'''The solution structure of a redesigned apocytochrome B562 (Rd-apocyt b562) with the N- and a part of the C-terminal helices unfolded''' | {{Structure | ||
|PDB= 1yzc |SIZE=350|CAPTION= <scene name='initialview01'>1yzc</scene> | |||
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'''The solution structure of a redesigned apocytochrome B562 (Rd-apocyt b562) with the N- and a part of the C-terminal helices unfolded''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1YZC is a [ | 1YZC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZC OCA]. | ||
==Reference== | ==Reference== | ||
A protein folding pathway with multiple folding intermediates at atomic resolution., Feng H, Zhou Z, Bai Y, Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5026-31. Epub 2005 Mar 25. PMID:[http:// | A protein folding pathway with multiple folding intermediates at atomic resolution., Feng H, Zhou Z, Bai Y, Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5026-31. Epub 2005 Mar 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15793003 15793003] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: berkeley structural genomics center]] | [[Category: berkeley structural genomics center]] | ||
[[Category: bsgc]] | [[Category: bsgc]] | ||
[[Category: folding | [[Category: folding intermediate]] | ||
[[Category: native-state hydrogen exchange]] | [[Category: native-state hydrogen exchange]] | ||
[[Category: nmr]] | [[Category: nmr]] | ||
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[[Category: protein structure initiative]] | [[Category: protein structure initiative]] | ||
[[Category: psi]] | [[Category: psi]] | ||
[[Category: structural | [[Category: structural genomic]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:29:22 2008'' | ||
Revision as of 13:29, 20 March 2008
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The solution structure of a redesigned apocytochrome B562 (Rd-apocyt b562) with the N- and a part of the C-terminal helices unfolded
Overview
Using native-state hydrogen-exchange-directed protein engineering and multidimensional NMR, we determined the high-resolution structure (rms deviation, 1.1 angstroms) for an intermediate of the four-helix bundle protein: Rd-apocytochrome b562. The intermediate has the N-terminal helix and a part of the C-terminal helix unfolded. In earlier studies, we also solved the structures of two other folding intermediates for the same protein: one with the N-terminal helix alone unfolded and the other with a reorganized hydrophobic core. Together, these structures provide a description of a protein folding pathway with multiple intermediates at atomic resolution. The two general features for the intermediates are (i) native-like backbone topology and (ii) nonnative side-chain interactions. These results have implications for important issues in protein folding studies, including large-scale conformation search, -value analysis, and computer simulations.
About this Structure
1YZC is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A protein folding pathway with multiple folding intermediates at atomic resolution., Feng H, Zhou Z, Bai Y, Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5026-31. Epub 2005 Mar 25. PMID:15793003
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