1z24: Difference between revisions
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'''The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution.''' | {{Structure | ||
|PDB= 1z24 |SIZE=350|CAPTION= <scene name='initialview01'>1z24</scene>, resolution 2.6Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=BLV:BILIVERDIN IX GAMMA CHROMOPHORE'>BLV</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution.''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1Z24 is a [ | 1Z24 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Manduca_sexta Manduca sexta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z24 OCA]. | ||
==Reference== | ==Reference== | ||
The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution., Holden HM, Rypniewski WR, Law JH, Rayment I, EMBO J. 1987 Jun;6(6):1565-70. PMID:[http:// | The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution., Holden HM, Rypniewski WR, Law JH, Rayment I, EMBO J. 1987 Jun;6(6):1565-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3608987 3608987] | ||
[[Category: Manduca sexta]] | [[Category: Manduca sexta]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: ins-a]] | [[Category: ins-a]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:30:23 2008'' | ||
Revision as of 13:30, 20 March 2008
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| 1z24, resolution 2.6Å | |||||||||||||
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| Ligands: | BLV | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution.
Overview
Insecticyanin, a blue biliprotein isolated from the tobacco hornworm Manduca sexta L., is involved in insect camouflage. Its three-dimensional structure has now been solved to 2.6 A resolution using the techniques of multiple isomorphous replacement, non-crystallographic symmetry averaging about a local 2-fold rotation axis and solvent flattening. All 189 amino acids have been fitted to the electron density map. The map clearly shows that insecticyanin is a tetramer with one of its molecular 2-fold axes coincident to a crystallographic dyad. The individual subunits have overall dimensions of 44 A X 37 A X 40 A and consist primarily of an eight-stranded anti-parallel beta-barrel flanked on one side by a 4.5-turn alpha-helix. Interestingly the overall three-dimensional fold of the insecticyanin subunit shows remarkable similarity to the structural motifs of bovine beta-lactoglobulin and the human serum retinol-binding protein. The electron density attributable to the chromophore is unambiguous and shows that it is indeed the gamma-isomer of biliverdin. The biliverdin lies towards the open end of the beta-barrel with its two propionate side chains pointing towards the solvent and it adopts a rather folded conformation, much like a heme.
About this Structure
1Z24 is a Single protein structure of sequence from Manduca sexta. Full crystallographic information is available from OCA.
Reference
The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution., Holden HM, Rypniewski WR, Law JH, Rayment I, EMBO J. 1987 Jun;6(6):1565-70. PMID:3608987
Page seeded by OCA on Thu Mar 20 15:30:23 2008
