3v0p: Difference between revisions
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{{STRUCTURE_3v0p| PDB=3v0p | SCENE= }} | {{STRUCTURE_3v0p| PDB=3v0p | SCENE= }} | ||
===Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (4GW) and H-antigen acceptor=== | ===Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (4GW) and H-antigen acceptor=== | ||
{{ABSTRACT_PUBMED_23836908}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. | |||
==About this Structure== | ==About this Structure== | ||
[[3v0p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_caccae Bacteroides caccae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0P OCA]. | [[3v0p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_caccae Bacteroides caccae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0P OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023836908</ref><references group="xtra"/><references/> | |||
[[Category: Bacteroides caccae]] | [[Category: Bacteroides caccae]] | ||
[[Category: Jorgensen, R.]] | [[Category: Jorgensen, R.]] | ||
Revision as of 05:32, 28 August 2013
Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (4GW) and H-antigen acceptor
Template:ABSTRACT PUBMED 23836908
Function
[BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
About this Structure
3v0p is a 2 chain structure with sequence from Bacteroides caccae. Full crystallographic information is available from OCA.
Reference
- Jorgensen R, Pesnot T, Lee HJ, Palcic MM, Wagner GK. Base-modified donor analogues reveal novel dynamic features of a glycosyltransferase. J Biol Chem. 2013 Jul 8. PMID:23836908 doi:10.1074/jbc.M113.465963
