2g0l: Difference between revisions

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[[Image:2g0l.png|left|200px]]
==Solution Structure of Neocarzinostatin Apo-Protein with bound Flavone==
<StructureSection load='2g0l' size='340' side='right' caption='[[2g0l]], [[NMR_Ensembles_of_Models | 58 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2g0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G0L FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLN:2-PHENYL-4H-CHROMEN-4-ONE'>FLN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j5h|1j5h]], [[1j5i|1j5i]], [[2g0k|2g0k]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ncsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1897 Streptomyces carzinostaticus])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g0l RCSB], [http://www.ebi.ac.uk/pdbsum/2g0l PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Neocarzinostatin (NCS) is a 1:1 complex of an enediyne chromophore (NCSChrom), non-covalently bound to an 11 kDa protein (apoNCS). We are exploring apoNCS as a generic protein system for sequestering small molecules for therapeutic applications. Here, we disclose a new flavone ligand 1 for apoNCS and present a high-resolution NMR structure of this ligand bound to apoNCS. This is the first high-resolution structure of a completely non-cognate ligand bound to the apoNCS protein. This work provides unambiguous evidence that a completely new class of ligand can bind specifically to apoNCS. Furthermore, the mode of binding is different than that of the naphthoate-based ligands, and for such a simple hydrophobic compound, the new ligand surprisingly binds specifically. This work indicates that apo-Neocarzinostatin has multiple selective and distinct binding modes for small-molecule cargo.


{{STRUCTURE_2g0l|  PDB=2g0l  |  SCENE=  }}
Synthetic ligands for apo-neocarzinostatin.,Caddick S, Muskett FW, Stoneman RG, Woolfson DN J Am Chem Soc. 2006 Apr 5;128(13):4204-5. PMID:16568976<ref>PMID:16568976</ref>


===Solution Structure of Neocarzinostatin Apo-Protein with bound Flavone===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_16568976}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[2g0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0L OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:016568976</ref><ref group="xtra">PMID:012269815</ref><references group="xtra"/>
[[Category: Streptomyces carzinostaticus]]
[[Category: Streptomyces carzinostaticus]]
[[Category: Caddick, S.]]
[[Category: Caddick, S.]]
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