2d9q: Difference between revisions
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{{STRUCTURE_2d9q| PDB=2d9q | SCENE= }} | {{STRUCTURE_2d9q| PDB=2d9q | SCENE= }} | ||
===Crystal Structure of the Human GCSF-Receptor Signaling Complex=== | |||
{{ABSTRACT_PUBMED_16492764}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CSF3R_HUMAN CSF3R_HUMAN]] Defects in CSF3R are the cause of hereditary neutrophilia (NEUTROPHILIA) [MIM:[http://omim.org/entry/162830 162830]]. A form of lifelong, persistent neutrophilia, a condition characterized by an increase in the number of neutrophils in the blood.<ref>PMID:19620628</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CSF3_HUMAN CSF3_HUMAN]] Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. [[http://www.uniprot.org/uniprot/CSF3R_HUMAN CSF3R_HUMAN]] Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.<ref>PMID:7514305</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:016492764</ref><ref group="xtra">PMID:014992583</ref><references group="xtra"/> | <ref group="xtra">PMID:016492764</ref><ref group="xtra">PMID:014992583</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Kuroki, R.]] | [[Category: Kuroki, R.]] | ||
