Cytochrome P450: Difference between revisions
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[[Cytochrome P450]] (P450) catalyzes the oxidation of organic substances like lipids. catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene. P450cam, also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor. P450nor is a Nitric Oxide Reductase P450. P450epoK converts epothilone D to epothilone B. P450cin monooxygenates 1,8-cineole which is similar to camphor. The images at the left and at the right correspond to one representative P450, ''i.e.'' the crystal structure of human P4502 ([[2f9q]]). For details on the human P45019 family see [[Aromatase]]. | [[Cytochrome P450]] (P450) catalyzes the oxidation of organic substances like lipids. catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene. P450cam, also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor. P450nor is a Nitric Oxide Reductase P450. P450epoK converts epothilone D to epothilone B. P450cin monooxygenates 1,8-cineole which is similar to camphor. The images at the left and at the right correspond to one representative P450, ''i.e.'' the crystal structure of human P4502 ([[2f9q]]). For details on the human P45019 family see [[Aromatase]]. Bifunctional P450/NADPH P450 reductase is a fatty acid monooxygenase. | ||
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===Bifunctional P450/NADPH P450 reductase=== | ===Bifunctional P450/NADPH P450 reductase=== | ||
[[3cbd – BmP450 domain – ''Bacillus megaterium''<br /> | [[3cbd]] – BmP450 domain – ''Bacillus megaterium''<br /> | ||
[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]] - BmP450 domain (mutant)<br /> | [[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]] - BmP450 domain (mutant)<br /> | ||
[[4dtw]], [[4due]], [[4duf]] - BmP450 domain (mutant) + serotonin<br /> | [[4dtw]], [[4due]], [[4duf]] - BmP450 domain (mutant) + serotonin<br /> | ||
