3zi4: Difference between revisions
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{{STRUCTURE_3zi4| PDB=3zi4 | SCENE= }} | |||
===The structure of Beta-phosphoglucomutase Inhibited With Glucose-6- phospahte and Scandium Tetrafluoride=== | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/PGMB_LACLA PGMB_LACLA]] Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.<ref>PMID:9084169</ref> <ref>PMID:15005616</ref> | |||
==About this Structure== | |||
[[3zi4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZI4 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Beta-phosphoglucomutase]] | |||
[[Category: Bowler, M W.]] | |||
[[Category: Pellegrini, E.]] | |||
[[Category: Experimental phasing]] | |||
[[Category: Isomerase]] | |||
[[Category: Phosphoryl transfer]] | |||
[[Category: Scandium tetrafluoride]] | |||
Revision as of 08:19, 15 January 2014
The structure of Beta-phosphoglucomutase Inhibited With Glucose-6- phospahte and Scandium Tetrafluoride
Function
[PGMB_LACLA] Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.[1] [2]
About this Structure
3zi4 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Qian N, Stanley GA, Bunte A, Radstrom P. Product formation and phosphoglucomutase activities in Lactococcus lactis: cloning and characterization of a novel phosphoglucomutase gene. Microbiology. 1997 Mar;143 ( Pt 3):855-65. PMID:9084169
- ↑ Lahiri SD, Zhang G, Dai J, Dunaway-Mariano D, Allen KN. Analysis of the substrate specificity loop of the HAD superfamily cap domain. Biochemistry. 2004 Mar 16;43(10):2812-20. PMID:15005616 doi:10.1021/bi0356810
