4i06: Difference between revisions
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{{STRUCTURE_4i06| PDB=4i06 | SCENE= }} | |||
===Crystal structure of human Arginase-2 complexed with inhibitor 14=== | |||
{{ABSTRACT_PUBMED_23472952}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN]] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. | |||
==About this Structure== | |||
[[4i06]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I06 OCA]. | |||
[[Category: Arginase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Andreoli, M.]] | |||
[[Category: Beckett ,P.]] | |||
[[Category: Conway, B.]] | |||
[[Category: Cousido-Siah, A.]] | |||
[[Category: Golebiowski, A.]] | |||
[[Category: Ji, M.]] | |||
[[Category: Mahboubi, K.]] | |||
[[Category: Mitschler, A.]] | |||
[[Category: Podjarny, A.]] | |||
[[Category: Ruiz, F X.]] | |||
[[Category: Schroeter, H.]] | |||
[[Category: Sheeler, R.]] | |||
[[Category: Whitehouse, D L.]] | |||
[[Category: Zandt, M C.Van.]] | |||
[[Category: Zhang, M.]] | |||
[[Category: Alpha/beta fold]] | |||
[[Category: Arginine metabolism]] | |||
[[Category: Hydrolase]] | |||
[[Category: Manganese]] | |||
[[Category: Metalloenzyme]] | |||
[[Category: Mitochondrion]] | |||
Revision as of 21:48, 10 April 2013
Crystal structure of human Arginase-2 complexed with inhibitor 14
Template:ABSTRACT PUBMED 23472952
Function
[ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
About this Structure
4i06 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
