2nsq: Difference between revisions
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{{STRUCTURE_2nsq| PDB=2nsq | SCENE= }} | {{STRUCTURE_2nsq| PDB=2nsq | SCENE= }} | ||
===Crystal structure of the C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein=== | ===Crystal structure of the C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein=== | ||
{{ABSTRACT_PUBMED_11840194}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NED4L_HUMAN NED4L_HUMAN]] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.<ref>PMID:12911626</ref> <ref>PMID:15217910</ref> <ref>PMID:15489223</ref> <ref>PMID:15040001</ref> <ref>PMID:15496141</ref> <ref>PMID:15576372</ref> <ref>PMID:19144635</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:011840194</ref>< | <ref group="xtra">PMID:011840194</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
