Sandbox Reserved 595: Difference between revisions
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New page: <!-- PLEASE DO NOT DELETE THIS TEMPLATE --> {{Sandbox_Reserved_Santoro_2013}} <!-- PLEASE ADD YOUR CONTENT BELOW HERE --> I would like the page to have a table of contents and the followin... |
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I would like the page to have a table of contents and the following main sections: Background, Structure (with a jmol image area), Function, Clinical Relevance, and References. | I would like the page to have a table of contents and the following main sections: Background, Structure (with a jmol image area), Function, Clinical Relevance, and References. | ||
===Background=== | |||
Apolipoprotein E is a member of the apolipoprotein family. This soluble apolipoprotein is produced primarily in the liver and brain; and it is located principally in the plasma and in the central nervous system (CNS) (AA). The systemic transport of cholesterol and other lipids is this protein's principle role in the body (W). One minor function it may exhibit is that of immune regulation (W). Particular isoforms, ε2 and ε4 implicated in hyperlipoproteinemia (HLP III) and late onset Alzheimer's disease (LOAD). ApoE may also play a role in synaptic integrity and plasticity (R). | |||
===Structure=== | |||
