Group:MUZIC:Plectin: Difference between revisions
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== Introduction == | == Introduction == | ||
Plectin is a multidomain protein with large size (>500kDa) and versatile binding properties, which abundantly expressed in a wide variety of mammalian tissues and cell types, combined with different binding partners. It has important functions in maintaining the mechanical stability of skin, skeletal muscle and heart. | Plectin is a multidomain protein with large size (>500kDa) and versatile binding properties, which abundantly expressed in a wide variety of mammalian tissues and cell types, combined with different binding partners. It has important functions in maintaining the mechanical stability of skin, skeletal muscle and heart. | ||
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'''3. Integrin β4-Plectin complex''' | '''3. Integrin β4-Plectin complex''' | ||
The interaction between the integrin α6β4 and plectin is essential for the assembly and stability of hemidesmosomes, which are junctional adhesion complexes that anchor epithelial cells to the basement membrane.<ref>PMID: 19242489 </ref> | The interaction between the integrin α6β4 and plectin is essential for the assembly and stability of hemidesmosomes, which are junctional adhesion complexes that anchor epithelial cells to the basement membrane.<ref>PMID: 19242489 </ref> | ||
== Function and Interactions == | == Function and Interactions == | ||
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The actin binding domain(ABD)in N-terminal globular domain has a role to interact with integrin subunit beta 4 to establish mechanical stability in hemedesmosomes along with its function for binding to actin filament(F-actin). Calmodulin(CaM) is also known to bind the ABD of plectin to modulate the hemidesmosome disassembly <ref> PMID: 19419971 </ref>. | The actin binding domain(ABD)in N-terminal globular domain has a role to interact with integrin subunit beta 4 to establish mechanical stability in hemedesmosomes along with its function for binding to actin filament(F-actin). Calmodulin(CaM) is also known to bind the ABD of plectin to modulate the hemidesmosome disassembly <ref> PMID: 19419971 </ref>. | ||
<Structure load='3F7P' size='300' frame='true' align='right' caption='Crystal structure of plectin ABD(magenta) and integrin beta 4 (green) complex (PDB:3F7P)' scene='Group:MUZIC:Plectin/Plecint/1' /> | |||
== Pathology == | == Pathology == | ||
